462. MAJOR PATHOLOGIC RESPONSE IN ESOPHAGEAL ADENOCARCINOMA: SHOULD WE ADOPT A NEW PARADIGM IN DEFINING RESPONSE TO TREATMENTS?
نویسندگان
چکیده
Abstract Background Incidence of adenocarcinoma (ADC) the esophagus is arising in Western countries and it still burdened by a significant mortality. A complete primary tumor regression after neoadjuvant treatment associated with improved long-term survival, however this favorable response rarely achieved. The endpoint study was to determine whether survival benefit could be achieved also major, albeit subtotal, response. Methods We evaluated all consecutive patients who underwent esophagectomy for cancer at 2 high-volume centers. Inclusion criteria were histologically confirmed ADC involving thoracic or Siewert I II cancers, treated chemotherapy (CT) chemoradiotherapy (CRT) surgery. Pathological quantified using Mandard score. Kaplan-Maier plots used estimate overall (OS) according TRG. Results Overall, 424 recruited period, 236 received CT 188 CRT. median follow-up time 55 months. TRG 1 showed comparable OS curves both group (p = 0.76) CRT 0.82) (Figure 1). 1–2 significantly compared 3–5 0.004) 0.0003). trend whole cohort, showing 5-years proportions (70% vs. 65%, p 0.52) < 0.0001). Conclusion Tumor long term irrespective adopted regimen. between population. This finding allowed us define criterion major response, which includes patients, potentially creating homogeneous larger subgroup subjects future clinical trials.
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BACKGROUND Alectinib is a highly selective tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK) and provided a significantly prolonged progression-free survival compared with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) harboring rearrangements of the ALK gene. Here, we present the first surgical case of ALK-rearranged lung adenocarcinoma with major patholo...
متن کاملMicroarray-based response prediction in esophageal adenocarcinoma.
PURPOSE In locally advanced (uT(3), N(+)) adenocarcinomas of the esophagus, neoadjuvant chemotherapy improves patient outcome. However, only a subgroup of patients responds. Therefore, in the present study, we evaluated whether the response to neoadjuvant chemotherapy can be predicted by a pretreatment tumor biopsy analysis. EXPERIMENTAL DESIGN Biopsies of 47 patients with locally advanced (u...
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ژورنال
عنوان ژورنال: Diseases of The Esophagus
سال: 2023
ISSN: ['1120-8694', '1442-2050']
DOI: https://doi.org/10.1093/dote/doad052.246